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small molecule library  (Selleck Chemicals)


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    Structured Review

    Selleck Chemicals small molecule library
    Small Molecule Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 73 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/small+molecule+library/Bioactive+Compound+Library-%E2%85%A1/pmc13006433-355-31-35
    Average 94 stars, based on 73 article reviews
    small molecule library - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Concentration Assay:

    Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer
    Article Snippet: .. RCC10, RCC10-VHL, RCC10-HIF-1α/2α-DKO, 786-O, or 786- O -HIF-2α-KO cells (1 × 10 4 /well) were seeded onto 96-well plates for 12 h. For the initial screen, cells were treated with a small molecule library (L1700, Selleckchem) at a final concentration of 5 μM for 72 h. For the second screen, cells were treated for 72 h with vehicle or a 7-point, 2-fold serial dilution of chemicals (10 or 20 μM as the highest concentration) for IC50 determination. ..

    Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
    Article Snippet: .. In vitro chemical screens RCC10, RCC10-VHL, RCC10-HIF-1α/2α-DKO, 786-O, or 786-O-HIF-2α-KO cells (1 × 10 4 /well) were seeded onto 96-well plates for 12 h. For the initial screen, cells were treated with a small molecule library (L1700, Selleckchem) at a final concentration of 5 μM for 72 h. For the second screen, cells were treated for 72 h with vehicle or a 7-point, 2-fold serial dilution of chemicals (10 or 20 μM as the highest concentration) for IC50 determination. ..

    Serial Dilution:

    Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer
    Article Snippet: .. RCC10, RCC10-VHL, RCC10-HIF-1α/2α-DKO, 786-O, or 786- O -HIF-2α-KO cells (1 × 10 4 /well) were seeded onto 96-well plates for 12 h. For the initial screen, cells were treated with a small molecule library (L1700, Selleckchem) at a final concentration of 5 μM for 72 h. For the second screen, cells were treated for 72 h with vehicle or a 7-point, 2-fold serial dilution of chemicals (10 or 20 μM as the highest concentration) for IC50 determination. ..

    Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
    Article Snippet: .. In vitro chemical screens RCC10, RCC10-VHL, RCC10-HIF-1α/2α-DKO, 786-O, or 786-O-HIF-2α-KO cells (1 × 10 4 /well) were seeded onto 96-well plates for 12 h. For the initial screen, cells were treated with a small molecule library (L1700, Selleckchem) at a final concentration of 5 μM for 72 h. For the second screen, cells were treated for 72 h with vehicle or a 7-point, 2-fold serial dilution of chemicals (10 or 20 μM as the highest concentration) for IC50 determination. ..

    In Vitro:

    Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
    Article Snippet: .. In vitro chemical screens RCC10, RCC10-VHL, RCC10-HIF-1α/2α-DKO, 786-O, or 786-O-HIF-2α-KO cells (1 × 10 4 /well) were seeded onto 96-well plates for 12 h. For the initial screen, cells were treated with a small molecule library (L1700, Selleckchem) at a final concentration of 5 μM for 72 h. For the second screen, cells were treated for 72 h with vehicle or a 7-point, 2-fold serial dilution of chemicals (10 or 20 μM as the highest concentration) for IC50 determination. ..

    Article Title: Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer.
    Article Snippet: The third-generation EGFR-TKI osimertinib is widely used in EGFR-mutated positive non-small cell lung cancer (NSCLC) patients, but drug resistance is inevitable.. The currently known mechanisms only explain resistance in a small proportion of patients.. For most patients, the mechanism of osimertinib resistance is still unclear, especially for EGFR-independent resistance.

    In Vivo:

    Article Title: Serotonin neuromodulation directs optic nerve regeneration.
    Article Snippet: .. Here, using this in vivo assay, we conducted a screen using a small molecule library (Selleckchem Bioactive) against defined molecular targets. ..

    Mutagenesis:

    Article Title: Inhibition of Cxcr4 chemokine receptor signaling improves habituation learning and increases cAMP-PKA signaling in a zebrafish model of Neurofibromatosis type 1
    Article Snippet: .. For the small-molecule screen, 1,134 bioactive compounds from an FDA-approved small-molecule library (Selleck) were tested on nf1 mutant larvae. ..

    Drug discovery:

    Article Title: Targeting proteostasis of the HEV replicase to combat infection in preclinical models.
    Article Snippet: https://doi.org/10.1016/j.jhep.2022.12.010 © 2022 European Association for the Study of the Liver.. Published by Elsevier B.V Appropriate treatment options for hepatitis E virus (HEV)infected pregnant women and immunocompromised patients are lacking; hence, there is an urgent need for safe and effective HEV-specific therapies.. This study identified new antivirals (inhibitors of HSP90) that significantly limit HEV infection by targeting the viral replicase for degradation.



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